2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1908):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113431
    Arabinosylhypoxanthine
    		99.0%
    Arabinosylhypoxanthine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Arabinosylhypoxanthine
  • HY-W011168
    8-Bromo-2'-deoxyguanosine
    		98.0%
    8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-2'-deoxyguanosine
  • HY-W013330
    3′-Deoxyguanosine
    3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism.
    3′-Deoxyguanosine
  • HY-W008048
    2',3'-O-Isopropylideneadenosine
    		99.97%
    2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2',3'-O-Isopropylideneadenosine
  • HY-W751165
    Uridine-13C9, 15N2
    		99.0%
    Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine-<sup>13</sup>C<sub>9</sub>, <sup>15</sup>N<sub>2</sub>
  • HY-W017749
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
    		≥98.0%
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue with antiviral activity.
    1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
  • HY-43057
    iBu-rG
    		99.74%
    iBu-rG (N-Isobutyrylguanosine) is a nucleoside compound that can be used to synthesize oligoribonucleotides.
    iBu-rG
  • HY-W018604
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
    		99.95%
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be synthesized from D-ribose by reacting with methanol under Fischer glycosylation conditions. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone exerts anticancer activities through inhibition of DNA synthesis, induction of apoptosis, etc. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be studied in anticancer research for lymphoid malignancies.
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
  • HY-111648
    6-O-Methyl Guanosine
    		99.65%
    6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.
    6-O-Methyl Guanosine
  • HY-130805
    5-Hydroxyuridine
    		98.94%
    5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Hydroxyuridine
  • HY-138586
    DMT-dC(ac) Phosphoramidite
    		99.76%
    DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
    DMT-dC(ac) Phosphoramidite
  • HY-146247A
    4'-Fluorouridine triphosphate sodium
    4'-Fluorouridine triphosphate (4'-Fluorouridine TP) sodium is a bioactive 5’-triphosphate form of 4'-Fluorouridine (EIDD-2749) (HY-146246). 4'-Fluorouridine triphosphate can effectively bind to RSV RdRP.
    4'-Fluorouridine triphosphate sodium
  • HY-137600
    1,N6-Ethenoadenosine
    		99.69%
    1,N6-Ethenoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,N6-Ethenoadenosine
  • HY-W007791
    Chloropurine riboside
    		99.93%
    Chloropurine riboside (6-Chloropurine riboside) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Purine nucleoside analogs represent cytotoxic agents with established activity in hematological malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Chloropurine riboside
  • HY-W009234
    6-Chloroguanineriboside
    		98.02%
    6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (Ki: 253.1 μM).
    6-Chloroguanineriboside
  • HY-123523
    Enocitabine
    		99.32%
    Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities.
    Enocitabine
  • HY-W091788
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
    		99.56%
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
  • HY-W251781
    4-Thio-2’-deoxyuridine
    		98.0%
    4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Thio-2’-deoxyuridine
  • HY-W013052
    8-Bromo-2'-deoxyadenosine
    		≥98.0%
    8-Bromo-2'-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-2'-deoxyadenosine
  • HY-W347492
    6-O-Methyldeoxyguanosine
    		99.61%
    O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-O-Methyldeoxyguanosine