2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013330
    3′-Deoxyguanosine
    3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3′-Deoxyguanosine
  • HY-B1449S8
    Uridine-d2-1
    		98.47%
    Uridine-d2-1 is the deuterium labeled Uridine.
    Uridine-d<sub>2</sub>-1
  • HY-B0158R
    Cytidine (Standard)
    		Chemical
    Cytidine (Standard) is the analytical standard of Cytidine. This product is intended for research and analytical applications. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function. In Vivo:Cytidine decreases glutamate/glutamine levels and induces earlier improvement of depressive symptoms.
    Cytidine (Standard)
  • HY-115741
    3BrB-PP1
    		≥99.0%
    3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket).
    3BrB-PP1
  • HY-113139S
    1-Methylinosine-d3
    		≥99.0%
    1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
    1-Methylinosine-d<sub>3</sub>
  • HY-W108399
    3’-O-t-Bulyldimethylsilylthymidine
    		99.04%
    3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-t-Bulyldimethylsilylthymidine
  • HY-W013259
    6-Methylmercaptopurine riboside
    		≥99.0%
    6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-Methylmercaptopurine riboside
  • HY-W751165
    Uridine-13C9, 15N2
    		≥99.0%
    Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine-<sup>13</sup>C<sub>9</sub>, <sup>15</sup>N<sub>2</sub>
  • HY-111641
    3'-Azido-3'-deoxy-5-fluorocytidine
    		99.90%
    3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative. 3'-Azido-3'-deoxy-5-fluorocytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxy-5-fluorocytidine
  • HY-114570
    Tiazofurin
    		Inhibitor 99.84%
    Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities.
    Tiazofurin
  • HY-138603
    5'-O-DMT-N4-Bz-2'-F-dC
    		99.85%
    5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.
    5'-O-DMT-N4-Bz-2'-F-dC
  • HY-106048
    Bredinin aglycone
    		99.82%
    Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues.
    Bredinin aglycone
  • HY-43057
    iBu-rG
    		99.74%
    iBu-rG (N-Isobutyrylguanosine) is a nucleoside compound that can be used to synthesize oligoribonucleotides.
    iBu-rG
  • HY-W018604
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
    		99.95%
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be synthesized from D-ribose by reacting with methanol under Fischer glycosylation conditions. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone exerts anticancer activities through inhibition of DNA synthesis, induction of apoptosis, etc. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be studied in anticancer research for lymphoid malignancies.
    2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
  • HY-138616S4
    dGTP-13C10,15N5 dilithium
    		98.2%
    dGTP-13C10,15N5 (2'-Deoxyguanosine-5'-triphosphate-13C10,15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    dGTP-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> dilithium
  • HY-134324
    8-Hydroxyadenosine
    		99.86%
    8-Hydroxyadenosine is a purine nucleoside.
    8-Hydroxyadenosine
  • HY-W014306
    2',3'-Dideoxyuridine
    		99.89%
    2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-Dideoxyuridine
  • HY-B0158S
    Cytidine-d2
    		Chemical ≥98.0%
    Cytidine-d2 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>2</sub>
  • HY-130805
    5-Hydroxyuridine
    		98.94%
    5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Hydroxyuridine
  • HY-137600
    1,N6-Ethenoadenosine
    		99.69%
    1,N6-Ethenoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,N6-Ethenoadenosine